CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors.

@article{Jacobson2000CRHDI,
  title={CRH deficiency impairs but does not block pituitary-adrenal responses to diverse stressors.},
  author={Lisa Paula Jacobson and Louis J. Muglia and Stacie C. Weninger and Karel Pacak and Joseph A. Majzoub},
  journal={Neuroendocrinology},
  year={2000},
  volume={71 2},
  pages={
          79-87
        }
}
We have previously observed significant, albeit decreased, corticosterone responses to restraint stress in corticotropin releasing hormone (CRH)-deficient (knockout, CRH KO) mice. Because different stressors have been shown to engage different populations of hypophysiotropic neurons, we have used hypoglycemia and hypovolemia to test whether CRH-independent pituitary-adrenal activation is evoked by stimuli other than restraint. Insulin injection in fasted CRH KO mice elicited increases in… CONTINUE READING
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