CRFergic innervation of the paraventricular nucleus of the rat hypothalamus: a tract-tracing study.

  title={CRFergic innervation of the paraventricular nucleus of the rat hypothalamus: a tract-tracing study.},
  author={David Champagne and J Beaulieu and Guy Drolet},
  journal={Journal of neuroendocrinology},
  volume={10 2},
It has been reported that corticotropin-releasing factor (CRF) may regulate its own biosynthesis in the paraventricular nucleus of the hypothalamus (PVH). Whether this CRF autoregulation is mediated by local circuitry or from extra-PVH CRF neuronal fibers terminating on CRF perikarya within the PVH is unknown. In the present study, we sought to determine the origin(s) of this CRF innervation using retrograde transport of wheat germ-conjugated-gold particles (WGA-apoHRP-Au) combined with… CONTINUE READING


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