CRF1 not glucocorticoid receptors mediate prepulse inhibition deficits in mice overexpressing CRF.

@article{Groenink2008CRF1NG,
  title={CRF1 not glucocorticoid receptors mediate prepulse inhibition deficits in mice overexpressing CRF.},
  author={Lucianne Groenink and Anneloes Dirks and P. Monika Verdouw and Marijke de Graaff and Bernard W. M. M. Peeters and Mark John Millan and Berend Olivier},
  journal={Biological psychiatry},
  year={2008},
  volume={63 4},
  pages={360-8}
}
BACKGROUND Both corticotropin-releasing factor (CRF) and glucocorticoid receptors (GR) are implicated in the psychotic symptoms of psychiatric disorders. Correspondingly, it is of interest to determine their respective involvement in the sensorimotor gating deficits displayed by transgenic mice overexpressing CRF. These mice reveal lifelong elevations of CRF and corticosterone levels. METHODS Effects of the GR antagonists ORG34517 (5-45 mg/kg by mouth [PO]) and mifepristone (5-45 mg/kg PO… CONTINUE READING