CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD.

@article{Adamec2010CRFRB,
  title={CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD.},
  author={Robert E. Adamec and Dennis Fougere and Victoria B Risbrough},
  journal={The international journal of neuropsychopharmacology},
  year={2010},
  volume={13 6},
  pages={747-57}
}
Post traumatic stress disorder (PTSD) is a chronic anxiety disorder initiated by an intensely threatening, traumatic event. There is a great need for more efficacious pharmacotherapy and preventive treatments for PTSD. In animals, corticotropin-releasing factor (CRF) and the CRF1 receptor play a critical role in behavioural and neuroendocrine responses to stress. We tested the hypothesis that CRF1 activation is required for initiation and consolidation of long-term effects of trauma on anxiety… CONTINUE READING
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