CRF-induced calcium signaling in guinea pig small intestine myenteric neurons involves CRF-1 receptors and activation of voltage-sensitive calcium channels.

@article{Bisschops2006CRFinducedCS,
  title={CRF-induced calcium signaling in guinea pig small intestine myenteric neurons involves CRF-1 receptors and activation of voltage-sensitive calcium channels.},
  author={Raf Bisschops and Pieter Vanden Berghe and Giovanni Sarnelli and Jozef Janssens and Jan Tack},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={290 6},
  pages={G1252-60}
}
Corticotropin-releasing factor (CRF) is a 41-amino acid peptide with distinct effects on gastrointestinal motility involving both CRF-1 and CRF-2 receptor-mediated mechanisms that are generally claimed to be centrally mediated. Evidence for a direct peripheral effect is rather limited. Electrophysiological studies showed a cAMP-dependent prolonged… CONTINUE READING