• Corpus ID: 29656408

CRF-dependent and CRF-independent mechanisms involved in hypophysial-adrenal system activation by bacterial endotoxin.

  title={CRF-dependent and CRF-independent mechanisms involved in hypophysial-adrenal system activation by bacterial endotoxin.},
  author={Ilia J. Elenkov and J{\'a}nos P. Kiss and E Stark and L{\'o}r{\'a}nd Bert{\'o}k},
  journal={Acta physiologica Hungarica},
  volume={79 4},
The immune system and the hypothalamic-pituitary-adrenal (HPA) axis play important role in the overall inflammatory response. The mechanism through which lipopolysaccharide (LPS, endotoxin) stimulates the HPA axis is not well understood. In order to clarify the role of hypophysiotropic peptides of paraventricular origin in the effect of LPS on ACTH and corticosterone secretion, the effect of LPS was studied on rats with lesions of hypothalamic paraventricular nucleus (PVN). It was shown that 90… 
Review: Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis
There appears to be a temporal and functional relation between the HPA-axis response to endotoxin and Nitric oxide formation in the neuro-endocrine hypothalamus, suggesting a stimulatory role for nitric oxide in modulating the H PA response to immune challenges.
Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint.
Lesioning of the mediobasal hypothalamus abolished the hormonal response and POMC mRNA activation to acute and/or repeated restraint, suggesting that the hypothalamo-pituitary-adrenal axis activation during repeated restraint is centrally driven.
Endotoxin tolerance of adrenal gland: Attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropic hormone*
Pre-exposure to lipopolysaccharide resulted in hyporesponsiveness to ACTH stimulation in rats, indicating that endotoxin tolerance of adrenal gland is one of the mechanisms for adrenocortical insufficiency during sepsis.
Bacterial lipopolysaccharide stimulates glucocorticoid secretion in hypophysectomized rats.
The hypothesis is advanced that LPS may activate hypothalamo- pituitary adrenal axis in rats, by stimulating not only the central (hypothalamo-pituitary), but also the peripheral (intra-adrenal) branch of the CRH/ACTH system.
Endotoxins and endocrine system.
  • L. Bertók
  • Biology, Medicine
    Domestic animal endocrinology
  • 1998
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LLPS redui la resposta de lmRNA de CRF en el PVN al mateix estimul 4, pero no 2, setmanes mes tard; the resposta periferica, aixi com the del TNF-a, tambe fou menor, tant 1 com 4 set manes mesTard.