• Corpus ID: 29656408

CRF-dependent and CRF-independent mechanisms involved in hypophysial-adrenal system activation by bacterial endotoxin.

@article{Elenkov1992CRFdependentAC,
  title={CRF-dependent and CRF-independent mechanisms involved in hypophysial-adrenal system activation by bacterial endotoxin.},
  author={Ilia J. Elenkov and J{\'a}nos P. Kiss and E Stark and L{\'o}r{\'a}nd Bert{\'o}k},
  journal={Acta physiologica Hungarica},
  year={1992},
  volume={79 4},
  pages={
          355-63
        }
}
The immune system and the hypothalamic-pituitary-adrenal (HPA) axis play important role in the overall inflammatory response. The mechanism through which lipopolysaccharide (LPS, endotoxin) stimulates the HPA axis is not well understood. In order to clarify the role of hypophysiotropic peptides of paraventricular origin in the effect of LPS on ACTH and corticosterone secretion, the effect of LPS was studied on rats with lesions of hypothalamic paraventricular nucleus (PVN). It was shown that 90… 
Review: Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis
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There appears to be a temporal and functional relation between the HPA-axis response to endotoxin and Nitric oxide formation in the neuro-endocrine hypothalamus, suggesting a stimulatory role for nitric oxide in modulating the H PA response to immune challenges.
Role of hypothalamic inputs in maintaining pituitary-adrenal responsiveness in repeated restraint.
TLDR
Lesioning of the mediobasal hypothalamus abolished the hormonal response and POMC mRNA activation to acute and/or repeated restraint, suggesting that the hypothalamo-pituitary-adrenal axis activation during repeated restraint is centrally driven.
Endotoxin tolerance of adrenal gland: Attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropic hormone*
TLDR
Pre-exposure to lipopolysaccharide resulted in hyporesponsiveness to ACTH stimulation in rats, indicating that endotoxin tolerance of adrenal gland is one of the mechanisms for adrenocortical insufficiency during sepsis.
Bacterial lipopolysaccharide stimulates glucocorticoid secretion in hypophysectomized rats.
TLDR
The hypothesis is advanced that LPS may activate hypothalamo- pituitary adrenal axis in rats, by stimulating not only the central (hypothalamo-pituitary), but also the peripheral (intra-adrenal) branch of the CRH/ACTH system.
Endotoxins and endocrine system.
  • L. Bertók
  • Biology, Medicine
    Domestic animal endocrinology
  • 1998
DOMESTIC ANIMAL ENDOCRINOLOGY Vol. 15(5):305-303, 1998 ENDOTOXINS AND ENDOCRINE SYSTEM
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The bile acids—as the end-product of cholesterol metabolism—play an important role in the physiological defense of macroorganisms against endotoxin and other lipid-like agents and in the regulation of endocrine system, including the reproduction.
Endotoxin stimulates secretion of cortisol, but not ACTH in heifers pretreated with suppressive doses of a glucocorticoid.
TLDR
The significant response of cortisol to LPS stimulation suggest that, at doses used in this study, triamcinolone acetonide did not suppress LPS-triggered cortisol secretion from adrenal zonae fasciculata and reticularis cells.
Brain changes underlying the long-term effects of a single previous exposure to emotional or systemic stressors in rats a view from the hypothalamic-pituitary-adrenal axis
TLDR
LLPS redui la resposta de lmRNA de CRF en el PVN al mateix estimul 4, pero no 2, setmanes mes tard; the resposta periferica, aixi com the del TNF-a, tambe fou menor, tant 1 com 4 set manes mesTard.
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