CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the β-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling*

@article{Zhang2014CREPTRPRD1BAR,
  title={CREPT/RPRD1B, a Recently Identified Novel Protein Highly Expressed in Tumors, Enhances the $\beta$-Catenin·TCF4 Transcriptional Activity in Response to Wnt Signaling*},
  author={Yanquan Zhang and Chunxiao Liu and Xiaoling Duan and F. Ren and Shan Li and Zhe Jin and Yinyin Wang and Yarui Feng and Zewen Liu and Z. Chang},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={289},
  pages={22589 - 22599}
}
Background: CREPT/RPRD1B promotes tumor growth through up-regulating CYCLIN D1 expression. Results: CREPT interacts with β-catenin in response to Wnt signaling and enhances the occupancy of β-catenin to promoters of Wnt-targeted genes, resulting in an up-regulation of expression. Conclusion: CREPT functions as a co-activator for β-catenin·TCF4. Significance: CREPT-regulated Wnt signaling implies an oncogenic role in promoting cell proliferation and invasion. CREPT (cell cycle-related and… Expand
CREPT/RPRD1B promotes tumorigenesis through STAT3-driven gene transcription in a p300-dependent manner.
TLDR
It is demonstrated that CREPT, a recently identified oncoprotein, enhances STAT3 transcriptional activity to promote tumorigenesis and provides an alternative strategy for the therapy of cancers related to STAT3. Expand
p15RS/RPRD1A (p15INK4b-related Sequence/Regulation of Nuclear Pre-mRNA Domain-containing Protein 1A) Interacts with HDAC2 in Inhibition of the Wnt/β-Catenin Signaling Pathway*
Background: p15RS/RPRD1A inhibits Wnt/β-catenin signaling by recruiting HDAC2. Results: p15RS interacts with HDAC2 and enhances the occupancy of HDAC2 to promoters of Wnt-targeted genes, keepingExpand
CREPT promotes glioma cell proliferation and invasion by activating Wnt/β-catenin pathway and is a novel target of microRNA-596.
TLDR
It is demonstrated that CREPT exerts an oncogenic role in glioma and its expression is regulated by microRNA-596, which highlights the important role miR-596/CREPT/Wnt/β-catenin signaling axis may play inglioma. Expand
MicroRNA‐383 acts as a tumor suppressor in colorectal cancer by modulating CREPT/RPRD1B expression
TLDR
The results revealed that the abundant expression of CREPT in colorectal cancers is attributed to the decreased level of miR‐383, which shed a new light on the potential therapeutic therapy strategy for coloreCTal cancers using introduced miRNA. Expand
Current understanding of CREPT and p15RS, carboxy-terminal domain (CTD)-interacting proteins, in human cancers
TLDR
Fully revealing the mechanisms of CREPT and p15RS functions will not only provide new insights into understanding gene transcription and maintenance of DNA stability in tumors, but also promote new approach development for tumor diagnosis and therapy. Expand
CREPT facilitates colorectal cancer growth through inducing Wnt/β-catenin pathway by enhancing p300-mediated β-catenin acetylation
TLDR
CREPT plays a pivotal oncogenic role in colorectal carcinogenesis through promoting Wnt/β-catenin pathway via cooperating with p300, and may serve as a prognostic biomarker of patients with CRC. Expand
CREPT/RPRD1B associates with Aurora B to regulate Cyclin B1 expression for accelerating the G2/M transition in gastric cancer
TLDR
This study provides a mechanism by which gastric tumor cells maintain their high proliferation rate via coordination of Aurora B and CREPT/RPRD1B on the expression of Cyclin B1. Expand
MicroRNA-449b-5p suppresses the growth and invasion of breast cancer cells via inhibiting CREPT-mediated Wnt/β-catenin signaling.
TLDR
The results reveal a tumor suppressive role of miR-449b-5p that restricts the growth and invasion of breast cancer cells through targeting CREPT and inhibiting CREPT-mediated activation of Wnt/β-catenin signaling. Expand
Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins
TLDR
This review addresses the accumulated evidence of the involvement of the HPV E6 and E7 oncoproteins in the activation of the Wnt/β-catenin pathway. Expand
Knocking-down of CREPT prohibits the progression of oral squamous cell carcinoma and suppresses cyclin D1 and c-Myc expression
TLDR
Up-regulated CREPT expression enhanced cell proliferation, migration and cell cycle as well as promoted cyclin D1 and c-Myc expression as it did in endoderm and mesoderm-origin tumors. Expand
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