CREBBP and WDR 24 Identified as Candidate Genes for Quantitative Variation in Red-Brown Plumage Colouration in the Chicken

  title={CREBBP and WDR 24 Identified as Candidate Genes for Quantitative Variation in Red-Brown Plumage Colouration in the Chicken},
  author={Jesper Fogelholm and Rie Henriksen and Andrey H{\"o}glund and Nafisa Nazmun Huq and Martin Johnsson and Regis Luis Sturm Lenz and Per Jensen and Dominic Wright},
  journal={Scientific Reports},
Plumage colouration in birds is important for a plethora of reasons, ranging from camouflage, sexual signalling, and species recognition. The genes underlying colour variation have been vital in understanding how genes can affect a phenotype. Multiple genes have been identified that affect plumage variation, but research has principally focused on major-effect genes (such as those causing albinism, barring, and the like), rather than the smaller effect modifier loci that more subtly influence… 
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New insights into genetics underlying of plumage color.
The results indicated that plumage color is a highly polygenic trait which, in turn, can be affected by multiple coding genes, regulatory genes and gene-gene epistasis interactions.
A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy
It is hypothesised that colour pattern polymorphism is driven by Y-autosome epistasis, and concluded that predictions of sexual conflict should focus on incorporating the effects of epistasis in understanding complex adaptive architectures.
Effects of the domestic thyroid stimulating hormone receptor (TSHR) variant on the hypothalamic-pituitary-thyroid axis and behavior in chicken.
It is confirmed that the spread of the domestic TSHR variant is limited to domesticated chickens, and to a lesser extent, their wild counterpart, the red junglefowl, and it was showed that effects of genetic variability in T SHR mirror key differences in gene expression and behavior previously described between the red Junglefowl and domestic chicken.


Genetic and environmental components of variation in eumelanin and phaeomelanin sex-traits in the barn owl
Despite plumage coloration and spottiness signalling different qualities, these two traits are not inherited independent of each other, darker birds being spottier than in females, which suggests that the extent to which Coloration and Spottiness are expressed depends on the total amount of melanin produced rather than on differential allocation of melanIn into plumageColoration andSpottiness.
A window on the genetics of evolution: MC1R and plumage colouration in birds
  • N. Mundy
  • Biology, Medicine
    Proceedings of the Royal Society B: Biological Sciences
  • 2005
Results show that melanism was a derived trait and allow other evolutionary inferences about the history of melanism to be made, and the role of MC1R in plumage patterning is surprisingly diverse among different species.
Melanocortin 1-receptor (MC1R) mutations are associated with plumage colour in chicken.
The results provided compelling evidence that the Extended black (E) locus controlling plumage colour is equivalent to MC1R, and E/MC1R was assigned to chromosome 11 with overwhelming statistical support.
The Dark brown plumage color in chickens is caused by an 8.3‐kb deletion upstream of SOX10
Genetic evidence is presented that an 8.3‐kb deletion upstream of the SOX10 transcription start site is the causal mutation underlying the DB phenotype, and it is demonstrated that the mouse homolog of a highly conserved element within the deleted region is a SoX10 enhancer.
The role of humans in facilitating and sustaining coat colour variation in domestic animals.
It is concluded that coat colour variability was probably not a pleiotropic effect of the selection for tameness, that coat colours most likely appeared very soon after the domestication process began, and that humans have been actively selecting for colour novelty and thus allowing for the proliferation of new mutations in coat colour genes.
A Sexual Ornament in Chickens Is Affected by Pleiotropic Alleles at HAO1 and BMP2, Selected during Domestication
The importance of pleiotropy (or extremely close linkage) in domestication is demonstrated using three separate intercrosses between wild and domestic chickens, and a locus affecting comb mass and several fitness traits was identified.
  • J. Smyth
  • Biology, Medicine
    Poultry science
  • 1965
Prior to the demonstration by the above of a wild type allele of E (designated as e+ by Kimball, 1951), it was generally accepted that extended black and the columbian restriction factor (e) were alleles.
A possible involvement of melanocortin 1-receptor in regulating feather color pigmentation in the chicken.
The finding that the structure of MC1-R was affected by individual E-locus alleles strongly suggests that MC1 -R is associated with the E- locus.
Missense and nonsense mutations in melanocortin 1 receptor (MC1R) gene of different goat breeds: association with red and black coat colour phenotypes but with unexpected evidences
The surprising not complete association of the nonsense mutation (p.Q225X) with red coat colour raises a few hypotheses on the determination of pheomelanic phenotypes in goats that should be further investigated.
Effect of the MC1R gene on sexual dimorphism in melanin‐based colorations
It is found that a valine (V)‐to‐isoleucine (I) substitution at position 126 explains up to 30% of the variation in the three melanin‐based colour traits and in feather melanin content, suggesting that a gene with major phenotypic effects and weakly influenced by variation in body condition can participate in sex‐specific selection processes.