CREB1 Genotype Modulates Adaptive Reward-Based Decisions in Humans.

@article{Wolf2016CREB1GM,
  title={CREB1 Genotype Modulates Adaptive Reward-Based Decisions in Humans.},
  author={Claudia Wolf and Holger Mohr and Esther Kristina Diekhof and Henning Vieker and Roberto Goya-Maldonado and Sarah Trost and Bernd Kr{\"a}mer and Maria Keil and Elisabeth B. Binder and Oliver Gruber},
  journal={Cerebral cortex},
  year={2016},
  volume={26 7},
  pages={
          2970-81
        }
}
Cyclic AMP response element-binding protein (CREB) contributes to adaptation of mesocorticolimbic networks by modulating activity-regulated transcription and plasticity in neurons. Activity or expression changes of CREB in the nucleus accumbens (NAc) and orbital frontal cortex (OFC) interact with behavioral changes during reward-motivated learning. However, these findings from animal models have not been evaluated in humans. We tested whether CREB1 genotypes affect reward-motivated decisions… 

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