CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.

@article{Ji1996CREBPF,
  title={CREB proteins function as positive regulators of the translocated bcl-2 allele in t(14;18) lymphomas.},
  author={Lili Ji and Evonne Mochon and Magdalena Arcinas and Linda M. Boxer},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 37},
  pages={22687-91}
}
The translocated and normal bcl-2 alleles in the DHL-4 cell line with the t(14;18) translocation were separated by pulsed field electrophoresis. An in vivo footprint over a cAMP response element (CRE) in the bcl-2 5'-flanking sequence was identified on the translocated allele. Electrophoretic mobility shift assays with the bcl-2 CRE demonstrated complexes with mobilities identical to those with a consensus CRE. UV cross-linking experiments revealed that proteins with molecular masses of 34, 43… CONTINUE READING

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