Corpus ID: 202628640

CREB is upregulated in hepatic encephalopathy and contributes to the neuroprotection against neuroinflammation

  title={CREB is upregulated in hepatic encephalopathy and contributes to the neuroprotection against neuroinflammation},
  author={Bin Cao and K-Y Ren and H. Yuan and W. Zhang and Qi Zhang},
Background: The cyclic adenosine monophosphate (cAMP) response element (CRE)-binding protein (CREB) is the key transcription factor in the brain which strengthens cell connection. This study was intended to determine whether CREB affect neurological decline in a hepatic encephalopathy animal model under trial conditions. Methods: Hepatic encephalopathy was induced in C57BL/6 mice via intraperitoneal injection of azoxymethane (AOM) in the presence or absence of 2-naphthol AS-E phosphate (KG-501… Expand

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