CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum.

@article{Levine2005CREBbindingPC,
  title={CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum.},
  author={Amir A. Levine and Zhonghui Guan and Angel Barco and Shiqin Xu and Eric R Kandel and James H. Schwartz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 52},
  pages={19186-91}
}
Remodeling chromatin is essential for cAMP-regulated gene expression, necessary not only for development but also for memory storage and other enduring mental states. Histone acetylation and deacetylation mediate long-lasting forms of synaptic plasticity in Aplysia as well as cognition in mice. Here, we show that histone acetylation by the cAMP-response element binding protein (CREB)-binding protein (CBP) mediates sensitivity to cocaine by regulating expression of the fosB gene and its splice… CONTINUE READING
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N Eu Ro Sc Ie N Ce

  • G. Lehrman, I. B. Hogue, +8 authors et. al
  • Levine et al. PNAS December
  • 2005

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