CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.

@article{Bordonaro2015CREBbindingPP,
  title={CREB-binding protein, p300, butyrate, and Wnt signaling in colorectal cancer.},
  author={Michael Bordonaro and Darina Lazarova Lazarova},
  journal={World journal of gastroenterology},
  year={2015},
  volume={21 27},
  pages={8238-48}
}
This paper reviews the distinctive roles played by the transcriptional coactivators CREB-binding protein (CBP) and p300 in Wnt/β-catenin signaling and cell physiology in colorectal cancer (CRC). Specifically, we focus on the effects of CBP- and p300-mediated Wnt activity on (1) neoplastic progression; (2) the activities of butyrate, a breakdown product of dietary fiber, on cell signaling and colonic cell physiology; (3) the development of resistance to histone deacetylase inhibitors (HDACis… CONTINUE READING
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