CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure.

@article{Tanis2008CREBBA,
  title={CREB binding and activity in brain: regional specificity and induction by electroconvulsive seizure.},
  author={Keith Quincy Tanis and Ronald S Duman and Samuel Sathyanesan Newton},
  journal={Biological psychiatry},
  year={2008},
  volume={63 7},
  pages={710-20}
}
BACKGROUND The transcription factor cyclic adenosine monophosphate response element binding protein (CREB) orchestrates diverse neurobiological processes including cell differentiation, survival, and plasticity. Alterations in CREB-mediated transcription have been implicated in numerous central nervous system (CNS) disorders including depression, anxiety, addiction, and cognitive decline. However, it remains unclear how CREB contributes to normal and aberrant CNS function, as the identity of… CONTINUE READING

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