CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

@article{Yin1995CREBAA,
  title={CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila},
  author={J.C.P. Yin and Mariangela Del Vecchio and H Zhou and Tim Tully},
  journal={Cell},
  year={1995},
  volume={81},
  pages={107-115}
}
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on… Expand
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