CREB and the formation of long-term memory

@article{Yin1996CREBAT,
  title={CREB and the formation of long-term memory},
  author={Jerry C. P. Yin and Tim Tully},
  journal={Current Opinion in Neurobiology},
  year={1996},
  volume={6},
  pages={264-268}
}

CREB Responsive Transcription and Memory Formation

TLDR
This chapter will review the molecular biology of CREB genes, before summarizing the work that demonstrates CREB is an important factor in memory formation, and addressing the more complex issue of why this requirement remains controversial.

Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior.

TLDR
It is shown that CREB phosphorylation at Ser133 is not necessary for CREB binding to CRE sites, CREB-mediated transcription, or CREb-mediated behavioral phenotypes associated with learning and memory.

dCREB2-Mediated Enhancement of Memory Formation

TLDR
It is reaffirmed that overexpression of a dCREB2 activator can enhance memory formation and the complexity of this behavioral enhancement is illustrated.

MAPK regulation of gene expression in the central nervous system.

TLDR
These studies indicate a critical role for the MAPK cascade in the regulation of CREB phosphorylation in the hippocampus, and evaluate the capacity of theMAPK ERK (extracellular signal-regulated kinase) to regulate phosphorylated cAMP response element binding protein in hippocampal area CA1.

CREB-mediated Enhancement of Hippocampus-dependent Memory Consolidation and Reconsolidation

TLDR
A gain-of-function approach is used to show that CREB (and CREB-coactivator CRTC1) can facilitate both synaptic and systems consolidation and reconsolidation in mice with brain-wide disrupted CREB function.

Viral‐mediated expression of a constitutively active form of CREB in hippocampal neurons increases memory

TLDR
There is direct evidence that a brief increase in CREB‐dependent transcription in either CA1 or DG neurons, using in vivo viral vectors, is sufficient to boost memory for contextual representations, as tested in the contextual fear conditioning task, without affecting motor, pain, or anxiety behaviors.

The Role of cAMP Response Element-Binding Protein in Drosophila Long-Term Memory

TLDR
It is shown that the dCREB2-a transgene originally reported to enhance LTM carries a mutation that produces a translational reading-frame shift with the consequent formation of a stop codon at predicted amino acid position 79, and an alternative model for the role of d CREB in Drosophila LTM is proposed.

Nuclear Calcium/Calmodulin Regulates Memory Consolidation

TLDR
It is shown that nuclear Ca2+/CaM signaling plays a critical role in memory consolidation in the mouse and is associated with diminished neuronal activity-induced phosphorylation of cAMP response element-binding protein.
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