CREB and its associated proteins act as survival factors for human melanoma cells.

@article{Jean1998CREBAI,
  title={CREB and its associated proteins act as survival factors for human melanoma cells.},
  author={Didier Jean and Madeleine D. Harbison and David James McConkey and Ze'ev A Ronai and Menashe M Bar-Eli},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 38},
  pages={24884-90}
}
cAMP response element-binding protein (CREB) and activating transcription factor 1 (ATF-1), members of the CREB/ATF family, have been implicated in cAMP- and calcium-induced transcriptional activation. We have previously demonstrated that quenching of CREB-associated proteins in metastatic melanoma cells by a dominant-negative CREB (KCREB) that is mutated within its DNA-binding domain decreased their radiation resistance, and their tumorigenic and metastatic potential in nude mice. As the… CONTINUE READING

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