CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium.

@article{Grimes2001CREBDB,
  title={CREB DNA binding activity is inhibited by glycogen synthase kinase-3 beta and facilitated by lithium.},
  author={Craigs A Grimes and Richard Scott Jope},
  journal={Journal of neurochemistry},
  year={2001},
  volume={78 6},
  pages={1219-32}
}
The regulatory influences of glycogen synthase kinase-3 beta (GSK3 beta) and lithium on the activity of cyclic AMP response element binding protein (CREB) were examined in human neuroblastoma SH-SY5Y cells. Activation of Akt (protein kinase B) with serum-increased phospho-serine-9-GSK3 beta (the inactive form of the enzyme), inhibited GSK3 beta activity, and increased CREB DNA binding activity. Inhibition of GSK3 beta by another paradigm, treatment with the selective inhibitor lithium, also… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 165 extracted citations

Similar Papers

Loading similar papers…