CRE and TRE sequences of the rat tyrosine hydroxylase promoter are required for TH basal expression in adult mice but not in the embryo.

@article{Trocm1998CREAT,
  title={CRE and TRE sequences of the rat tyrosine hydroxylase promoter are required for TH basal expression in adult mice but not in the embryo.},
  author={Candice Trocm{\'e} and Chamsy Sarkis and J M Hermel and Robbert Duchateau and Stephen Harrison and Michel Simonneau and Raya Al-Shawi and Jacques Mallet},
  journal={The European journal of neuroscience},
  year={1998},
  volume={10 2},
  pages={508-21}
}
Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, is expressed in a restricted number of areas, and subject to numerous regulations during development and in adulthood. Two transcription factor binding sites present in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been shown to play important roles in TH gene regulation in vitro. In order to elucidate in vivo the role of… CONTINUE READING

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