CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling

@article{Noubissi2006CRDBPMS,
  title={CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling},
  author={Felicite K Noubissi and Irina Elcheva and Neehar Bhatia and Abbas Shakoori and Andrei Ougolkov and Jianghuai Liu and Toshinari Minamoto and Jeff Ross and Serge Yu. Fuchs and Vladimir S. Spiegelman},
  journal={Nature},
  year={2006},
  volume={441},
  pages={898-901}
}
Although constitutive activation of β-catenin/Tcf signalling is implicated in the development of human cancers, the mechanisms by which the β-catenin/Tcf pathway promotes tumorigenesis are incompletely understood. Messenger RNA turnover has a major function in regulating gene expression and is responsive to developmental and environmental signals. mRNA… CONTINUE READING