CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.

@article{Perel2012CRASH2R,
  title={CRASH-2 (Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage) intracranial bleeding study: the effect of tranexamic acid in traumatic brain injury--a nested randomised, placebo-controlled trial.},
  author={Pablo Perel and Rustam Al-Shahi Salman and Tomoko Kawahara and Zoe Morris and David Prieto-Merino and Ian Roberts and Peter Ag Sandercock and Haleema Shakur and Joanna M. Wardlaw},
  journal={Health technology assessment},
  year={2012},
  volume={16 13},
  pages={
          iii-xii, 1-54
        }
}
BACKGROUND Tranexamic acid (TXA) has been shown to reduce blood loss in surgical patients and the risk of death in patients with traumatic bleeding, with no apparent increase in vascular occlusive events. These findings raise the possibility that it might also be effective in traumatic brain injury (TBI). OBJECTIVE The Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage Intracranial Bleeding Study (CRASH-2 IBS) was conducted to quantify the effect of an early short course… CONTINUE READING
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