CR 2249: a New Putative Memory Enhancer. Behavioural Studies on Learning and Memory in Rats and Mice

@article{Garofalo1996CR2A,
  title={CR 2249: a New Putative Memory Enhancer. Behavioural Studies on Learning and Memory in Rats and Mice},
  author={Paolo Garofalo and Sergio L Colombo and Marco Lanza and Laura Revel and Francesco Makovec},
  journal={Journal of Pharmacy and Pharmacology},
  year={1996},
  volume={48}
}
The effects of S‐4‐amino‐5‐[4,4‐dimethylcyclohexyl)amino]‐5‐oxopentanoic acid (CR 2249), a new entity selected from a new series of glutamic acid derivatives, has been investigated in different paradigms for screening nootropics. 
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18 Citations
Background Citations
4
Methods Citations
2

18 Citations

Cognition Enhancing Profile of CR 2249, a New NMDA‐Glycine Site Modulator
TLDR
Two different neurotransmission models are of major interest in understanding how the brain can acquire and store a single cognitive event: long-term potentiation and glutamatergic.
Characterization of a novel putative cognition enhancer mediating facilitation of glycine effect on strychnine-resistant sites coupled to NMDA receptor complex
The "kynurenate test", a biochemical assay for putative cognition enhancers.
TLDR
The "kynurenate test" is an in vitro assay useful in the identification and characterization of putative cognition enhancers acting via NMDA receptors and may bind to sites different from the glycine site of the NMDA receptor.
Activity of putative cognition enhancers in kynurenate test performed with human neocortex slices.
TLDR
The similarities between the data obtained here with human neocortex slices and those previously obtained in the rat indicate that the kynurenate test performed with rat brain slices may represent a useful biochemical assay to study cognition-enhancing drugs.
Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat.
Dopaminergic Control of Kynurenate Levels and N-Methyl-D-Aspartate Toxicity in the Developing Rat Striatum
TLDR
Data suggest that KYNA plays a role as a mediator of dopamine-glutamate interactions in the rat striatum and the possible functional significance of the reduction in KYNA levels was tested.
The Potential Effect of Caffeine and Nicotine Co-administration againstAluminum-induced Alzheimer's disease in Rats
TLDR
Co-administration of caffeine and nicotine can reduce the risk of neuronal degeneration in the hippocampus and attenuate the impairment of learning and memory associated with AD.
The role of MAPK signaling pathway in selenium amelioration of high fat/high cholesterol diet-induced tauopathy in rats.
Behavioral and neurochemical changes induced by post-weaning female rats isolation
TLDR
Collectively female rats post weaning isolation had significantly prompted both behavioral and neurochemical changes which could represent the essential important symptoms of schizophrenia.
Study of the Anxiolytic Activity of Captopril Against the Anxiogenic Potential of Ciprofloxacin in Different Models of Anxiety in Rats
TLDR
It could be concluded that the anxiolytic activity of captopril on rats predominates over the anxiogenic behavior of ciprofloxacin in mild and high stressful condition, and increases sensitivity to acute or electrically-evoked pain.
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