CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells.


PURPOSE We previously identified novel thiazole derivatives able to reduce histone acetylation and histone acetyltransferase (HAT) activity in yeast. Among these compounds, 3-methylcyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl]hydrazone (CPTH6) has been selected and used throughout this study. EXPERIMENTAL DESIGN The effect of CPTH6 on histone… (More)
DOI: 10.1158/1078-0432.CCR-11-0579


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