CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans.

@article{Chang2006CPS1AH,
  title={CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans.},
  author={Y. C. Chang and Ambrose Jong and Sheng-He Huang and Patricia M. Zerfas and Kyung J. Kwon-Chung},
  journal={Infection and immunity},
  year={2006},
  volume={74 7},
  pages={3930-8}
}
The polysaccharide capsule is known to be the major factor required for the virulence of Cryptococcus neoformans. We have cloned and characterized a gene, designated CPS1, that encodes a protein containing a glycosyltransferase moiety and shares similarity with the type 3 polysaccharide synthase encoded by the cap3B gene of Streptococcus pneumoniae. Cps1p also shares similarity with hyaluronan synthase of higher eukaryotes. Deletion of the CPS1 gene from a serotype D strain of C. neoformans… CONTINUE READING

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