CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells.

@article{Gamen1996CPP32IP,
  title={CPP32 inhibition prevents Fas-induced ceramide generation and apoptosis in human cells.},
  author={Susana Gamen and Isabel Marzo and Alberto Anel and A. L{\'o}pez Pi{\~n}eiro and J. M. Goldspiel U. S. Naval},
  journal={FEBS letters},
  year={1996},
  volume={390 2},
  pages={232-7}
}
Intracellular activation of sphingomyelinase, leading to ceramide generation, and ICE-like proteases have been implicated in TNF and Fas-induced apoptosis, but the links between these intracellular apoptotic mediators remain undefined. We show here that a specific peptide inhibitor of the ICE-like protease CPP32/Yama (DEVD-CHO) blocks anti-Fas-induced apoptosis in Jurkat and U937 cells, while having no effect on TNF-induced apoptosis in U937 cells. This peptide also prevents ceramide… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

Similar Papers

Loading similar papers…