CPG2 A brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors

@article{Cottrell2004CPG2AB,
  title={CPG2 A brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors},
  author={Jeffrey Richard Cottrell and Erzsebet Borok and Tam{\'a}s L. Horv{\'a}th and Elly Nedivi},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={677-690}
}
Long-term maintenance and modification of synaptic strength involve the turnover of neurotransmitter receptors. Glutamate receptors are constitutively and acutely internalized, presumptively through clathrin-mediated receptor endocytosis. Here, we show that cpg2 is a brain-specific splice variant of the syne-1 gene that encodes a protein specifically localized to a postsynaptic endocytotic zone of excitatory synapses. RNAi-mediated CPG2 knockdown increases the number of postsynaptic clathrin… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

A set of genes expressed in response to light in the adult cerebral cortex and regulated during development.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Molecular analysis of developmental plasticity in neocortex.

  • Journal of neurobiology
  • 1999
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

ANChors away : an actin basedand synaptic plasticity

M. Han
  • Annu . Rev . Neurosci . J . Cell Sci .
  • 2003
VIEW 1 EXCERPT

Actin assembly and endocytosis: from yeast to mammals.

  • Annual review of cell and developmental biology
  • 2003
VIEW 1 EXCERPT