CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation.

@article{Galardi2016CPEB1RP,
  title={CPEB1 restrains proliferation of Glioblastoma cells through the regulation of p27(Kip1) mRNA translation.},
  author={Silvia Galardi and Massimo Petretich and Guillaume Pinna and Silvia D'Amico and Fabrizio Loreni and Alessandro Michienzi and Irina Groisman and Silvia Anna Ciafr{\'e}},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={25219}
}
The cytoplasmic element binding protein 1 (CPEB1) regulates many important biological processes ranging from cell cycle control to learning and memory formation, by controlling mRNA translation efficiency via 3' untranslated regions (3'UTR). In the present study, we show that CPEB1 is significantly downregulated in human Glioblastoma Multiforme (GBM) tissues and that the restoration of its expression impairs glioma cell lines growth. We demonstrate that CPEB1 promotes the expression of the cell… CONTINUE READING

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