CPEB: a life in translation.

  title={CPEB: a life in translation.},
  author={Joel D. Richter},
  journal={Trends in biochemical sciences},
  volume={32 6},
Nearly two decades ago, Xenopus oocytes were found to contain mRNAs harboring a small sequence in their 3' untranslated regions that control cytoplasmic polyadenylation and translational activation during development. This cytoplasmic polyadenylation element (CPE) is the binding platform for CPE-binding protein (CPEB), which promotes polyadenylation-induced translation. Since then, the biochemistry and biology of CPEB has grown rather substantially: mechanistically, CPEB nucleates a complex of… CONTINUE READING
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