• Corpus ID: 9054023

CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

  title={CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.},
  author={Stephan Litschig and Fabrizio Gasparini and D Rueegg and Natacha Stoehr and Peter Josef Flor and Ivo Vranesic and Laurent Prézeau and Jean-Philippe Pin and Christian Thomsen and Rainer Kuhn},
  journal={Molecular pharmacology},
  volume={55 3},
Metabotropic glutamate receptors (mGluRs) are a family of G protein-coupled receptors characterized by a large, extracellular N-terminal domain comprising the glutamate-binding site. In the current study, we examined the pharmacological profile and site of action of the non-amino-acid antagonist 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester (CPCCOEt). CPCCOEt selectively inhibited glutamate-induced increases in intracellular calcium at human mGluR1b (hmGluR1b) with an… 

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