CP0569, a new broad-spectrum injectable carbapenem. Part 1: synthesis and structure-activity relationships.

@article{Aihara2003CP0569AN,
  title={CP0569, a new broad-spectrum injectable carbapenem. Part 1: synthesis and structure-activity relationships.},
  author={Kazuhiro Aihara and Yuko Kano and Sohjiro Shiokawa and Toshiro Sasaki and Fumihito Setsu and Yumiko Sambongi and Miyuki Ishii and K. Tohyama and Takashi Ida and Atsushi Tamura and Kunio Atsumi and Katsuyoshi Iwamatsu},
  journal={Bioorganic \& medicinal chemistry},
  year={2003},
  volume={11 16},
  pages={
          3475-85
        }
}
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9 Citations

9 Citations

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2-{2-[3-(1-Adamantyl)-4-fluorophenyl]thiazol-4-yl}ethan-1-amine and 2-{1-adamantyl)phenyl[4-(2-adammyantyl)]thiazolin[4- phenyl]-thiazolate exhibit activity against T. brucei in the range of IC50 = 0.42 μM and 0.80 μM.

Resistance to β-lactam antibiotics

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The concise total synthesis of largazole was accomplished. The key step included the use of the Nagao thiazolidinethione auxiliary for the diastereoselective acetate aldol reaction and it acts as an…

CP0569, A New Broad-Spectrum Injectable Carbapenem. Part 1. Synthesis and Structure—Activity Relationships.

References

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The reaction of chloroform with 2-(aminomethyl) pyridine (1) under basic phase-transfer catalysis affords the highly fluorescent imidazo [1,5-a] pyridine (2) in 25% isolated yield. The basic phase…