CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.

  title={CP-84,657, a potent polyether anticoccidial related to portmicin and produced by Actinomadura sp.},
  author={John P. Dirlam and A. M. Belton and Jon Bordner and Walter Patrick Cullen and L. H. Huang and Yasuhiro Kojima and Hiroshi Maeda and Hiroyuki Nishida and Satoshi Nishiyama and John R. Oscarson},
  journal={The Journal of antibiotics},
  volume={43 6},
A new polyether antibiotic CP-84,657 (C45H78O14) was isolated by solvent extraction from the fermentation broth of Actinomadura sp. (ATCC 53708). Following purification by column chromatography and crystallization, the structure of CP-84,657 was elucidated by spectroscopic (NMR and MS) methods. The absolute stereochemistry was determined by a single crystal X-ray analysis of the corresponding rubidium salt. CP-84,657 is among the most potent anticoccidal agents known, effectively controlling… 

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