COX-2 specific inhibitors in NSAID-intolerant patients.

  • P Picado
  • Published 2003 in
    International journal of immunopathology and…


Most adverse NSAID-induced respiratory and skin reactions appear to be precipitated by the inhibition of cyclooxygenase-1 (COX-1); this in turn activates the lypoxygenase pathway, which eventually increases the release of cysteinyl leukotrienes (Cys-LTs). Recent studies have reported that patients with NSAID-induced asthma have a low production of PGE2 in… (More)


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