COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?

@article{Jackson2000COX2SN,
  title={COX-2 selective nonsteroidal anti-Inflammatory drugs: do they really offer any advantages?},
  author={Lorna Jackson and Christopher John Hawkey},
  journal={Drugs},
  year={2000},
  volume={59 6},
  pages={
          1207-16
        }
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for substantial morbidity and mortality as a result of the complications associated with gastroduodenal ulcers, such as perforation and bleeding. The central mechanism leading to the gastroduodenal toxicity of NSAIDs is their ability to inhibit mucosal prostaglandin synthesis. Recent recognition that there are 2 isoforms of the enzyme cyclooxygenase (COX) responsible for prostaglandin synthesis has enabled the development of drugs… CONTINUE READING
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