COX-2-selective inhibitors in the treatment of arthritis.

  title={COX-2-selective inhibitors in the treatment of arthritis.},
  author={Thomas J. Schnitzer and Marc C. Hochberg},
  journal={Cleveland Clinic journal of medicine},
  volume={69 Suppl 1},
Therapy with nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has long been the cornerstone of pharmacologic management of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Many patients with OA or RA, however, are at increased risk of developing clinically significant adverse events associated with NSAID therapy, particularly upper gastrointestinal (GI) complications including symptomatic and complicated ulcers. The introduction of cyclooxygenase (COX)-2-selective… CONTINUE READING


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