COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.

@article{Supuran2004COX2SI,
  title={COX-2 selective inhibitors, carbonic anhydrase inhibition and anticancer properties of sulfonamides belonging to this class of pharmacological agents.},
  author={Claudiu T. Supuran and Angela Casini and Antonio Mastrolorenzo and Andrea Scozzafava},
  journal={Mini reviews in medicinal chemistry},
  year={2004},
  volume={4 6},
  pages={625-32}
}
The sulfonamides constitute an important class of drugs, with several types of pharmacological agents possessing antibacterial, anti-carbonic anhydrase, diuretic, hypoglycaemic, antithyroid, protease inhibitory and anticancer activity among others. A recently developed class of pharmacological agents incorporating primary sulfamoyl moieties in their molecule is constituted by the COX-2 selective inhibitors, with at least two clinically used drugs, celecoxib and valdecoxib. Another drug of this… CONTINUE READING
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