COX-2 polymorphisms and the risk for head and neck cancer in white patients.

@article{Peters2009COX2PA,
  title={COX-2 polymorphisms and the risk for head and neck cancer in white patients.},
  author={Wilbert H. M. Peters and Martin Lacko and Ren{\'e} HM te Morsche and A C Voogd and Michael B Oude Ophuis and Johannes Jan Manni},
  journal={Head & neck},
  year={2009},
  volume={31 7},
  pages={938-43}
}
BACKGROUND Cyclooxygenase-2 (COX-2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether functional genetic polymorphisms in COX-2 may have a risk-modifying effect on head and neck carcinogenesis. METHODS Blood from 431 white patients with oral, pharyngeal, or laryngeal carcinoma and 438 white healthy controls was… CONTINUE READING

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