COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.

  title={COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.},
  author={Juli{\"e}t H Hoff and Rene te Morsche and Hennie M. J. Roelofs and Elise M. J. van der Logt and Fokko M. Nagengast and Wilbert H. M. Peters},
  journal={World journal of gastroenterology},
  volume={15 36},
AIM To determine the possible modulating effect of the COX-2 polymorphisms, -765G-->C and -1195A-->G, on the risk of colorectal cancer (CRC) in a Dutch population. METHODS This case-control study includes 326 patients with CRC and 369 age- and gender-matched controls. Genotypes of the COX-2 polymorphisms -765G-->C and -1195A-->G were determined by polymerase chain reaction-based restriction fragment length polymorphism. COX-2 genotypes and haplotypes were analyzed and odds ratios with 95… CONTINUE READING

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COX-2: a molecular target

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  • Ann Intern Med
  • 2002

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