COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis.

Abstract

Cyclooxygenase (COX)-2 is upregulated in a variety of human cancers, including in hepatocellular carcinoma (HCC), whereas it is undetectable in most normal tissue. Evidence suggests that COX-2 is likely to be involved in hepatocarcinogenesis and, thus, COX-2 may be involved in an early process in carcinogenesis, dedifferentiation. To address this… (More)

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Cite this paper

@article{Yamanaka2006COX2IS, title={COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis.}, author={Yutaka Yamanaka and Katsuya Shiraki and Tomoko Inoue and Kazumi Miyashita and Hiroyuki Fuke and Yumi Yamaguchi and N. Yamamoto and Keiichi Ito and Kazushi Sugimoto and Takeshi Nakano}, journal={International journal of molecular medicine}, year={2006}, volume={18 1}, pages={41-7} }