COX-2 inhibitors: a novel strategy in the management of breast cancer.

@article{Regulski2016COX2IA,
  title={COX-2 inhibitors: a novel strategy in the management of breast cancer.},
  author={Miłosz Regulski and Katarzyna Regulska and Wiesław Prukała and Hanna Piotrowska and Beata Jadwiga Stanisz and Marek Murias},
  journal={Drug discovery today},
  year={2016},
  volume={21 4},
  pages={598-615}
}
Cyclooxygenase-2 (COX-2) inhibitors are common anti-inflammatory drugs with pleiotropic, endogenous actions that could be useful in the management of breast cancer. Here, we provide a complete understanding of the biochemistry of COX-2 and discuss the various molecular mechanisms behind its increased expression in breast cancer. We also analyze the possible mechanisms responsible for the anticancer effect of COX-2 inhibitors and provide an overview of the available preclinical and clinical data… CONTINUE READING