COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma.

@article{Song2007COX2IB,
  title={COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma.},
  author={Shumei Song and Sushovan Guha and Kaifeng Liu and Navtej S. Buttar and Robert S. Bresalier},
  journal={Gut},
  year={2007},
  volume={56 11},
  pages={1512-21}
}
OBJECTIVES Bile reflux contributes to oesophageal injury and neoplasia. COX-2 is involved in both inflammation and carcinogenesis; however, the precise mechanisms by which bile acids promote COX-2 expression in the oesophagus are largely unknown. We analysed the molecular mechanisms that govern bile acid-mediated expression of COX-2 in Barrett's oesophagus and oesophageal adenocarcinoma (OA). DESIGN The effects of bile acids on COX-2 expression were analysed in immortalised Barrett's… CONTINUE READING