COX-2 induction by heparanase in the progression of breast cancer.

  title={COX-2 induction by heparanase in the progression of breast cancer.},
  author={Takako Imada and J. A. Matsuoka and Tetsuji Nobuhisa and Takaomi Okawa and Toshihiro Murata and Yoko Tabuchi and Yasuhiro Shirakawa and Nobuya Ohara and Mehmet Gunduz and Hitoshi Nagatsuka and Tatsuo Umeoka and Yasuhisa Yamamoto and Motowo Nakajima and Noriaki Tanaka and Yoshio Naomoto},
  journal={International journal of molecular medicine},
  volume={17 2},
Breast cancer confined within the lactiferous duct or lobule, without invading the stroma, is called ductal carcinoma in situ (DCIS), whereas breast cancer that has invaded the stroma through the basal membrane is called invasive cancer. Heparanase, an endo-beta-D-glucuronidase that specifically degrades heparan sulfate proteoglycans (HSPGs) in the extracellular matrix (ECM), plays an important role when breast cancer cells breach the basal membrane. Recently, we have reported that heparanase… CONTINUE READING


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