COX-2 induces IL-11 production in human breast cancer cells.

  title={COX-2 induces IL-11 production in human breast cancer cells.},
  author={Balraj Singh and Jacob A Berry and Angela Shoher and Anthony J. Lucci},
  journal={The Journal of surgical research},
  volume={131 2},
BACKGROUND Cyclooxygenase-2 (COX-2) is overexpressed in 40% of human invasive breast cancers. Interleukin-11 (IL-11), a potent mediator of osteoclastogenesis, is involved in breast cancer metastasis to bone. Since breast cancers that overexpress COX-2 are associated with a higher rate of metastasis to bone, we hypothesized that COX-2 expression in tumor cells would induce IL-11. MATERIALS AND METHODS We transfected MCF-7 (poorly metastatic) and MDA-231 (highly metastatic) human breast cancer… CONTINUE READING


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