COX-2 expression and tumor angiogenesis in colorectal cancer.

  title={COX-2 expression and tumor angiogenesis in colorectal cancer.},
  author={Ai-wen Wu and Jin Gu and Zhen-fu Li and Jiafu Ji and Guang-wei Xu},
  journal={World journal of gastroenterology},
  volume={10 16},
AIM Cyclooxygenase-2 (COX-2) is one of the rate-limiting enzymes in metabolism of arachidonic acid, and COX-2 inhibitors demonstrate preventive effects on cancer, especially on colorectal cancer. The underlying mechanism remains unclear. The aim of this study was to illustrate the relationship between angiogenesis and COX-2 in carcinogenesis of colorectal cancer. METHODS One hundred and seventy patients with colorectal cancer were enrolled in our study from January 1993 to September 2001 in… CONTINUE READING