COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis.

@article{Lovgren2006COX2derivedPP,
  title={COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis.},
  author={Alysia Kern Lovgren and Leigh A. Jania and John M. Hartney and Kelly K. Parsons and Laurent P. Audoly and Garret A. FitzGerald and Stephen L. Tilley and Beverly H. Koller},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2006},
  volume={291 2},
  pages={
          L144-56
        }
}
Prostacyclin is one of a number of lipid mediators elaborated from the metabolism of arachidonic acid by the cyclooxygenase (COX) enzymes. This prostanoid is a potent inhibitor of platelet aggregation, and its production by endothelial cells and protective role in the vasculature are well established. In contrast, much less is known regarding the function of this prostanoid in other disease processes. We show here that COX-2-dependent production of prostacyclin plays an important role in the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 62 CITATIONS

FILTER CITATIONS BY YEAR

2006
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

  • Averaged 3 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

Similar Papers

Loading similar papers…