COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin.

@article{Brian2001COX2dependentDD,
  title={COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin.},
  author={Johnny E. Brian and Frank M. Faraci and Steven A. Moore},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 5},
  pages={H2023-9}
}
Bradykinin (BK) is released in the brain during injury and inflammation. Activation of endothelial BK receptors produces acute dilatation of cerebral arterioles that is mediated by reactive oxygen species (ROS). ROS can also modulate gene expression, including expression of the inducible isoform of cyclooxygenase (COX-2). We hypothesized that exposure of the brain to BK would produce acute dilatation, which would be followed by a delayed dilatation mediated by COX-2. To test this hypothesis in… CONTINUE READING

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