COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

  title={COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models},
  author={Ling Xu and Janine Stevens and Mary Beth Hilton and Steven Seaman and Thomas P. Conrads and Timothy D. Veenstra and Daniel Logsdon and Holly Morris and Deborah A. Swing and Nimit L. Patel and Joseph D. Kalen and Diana C. Haines and Enrique Zudaire and Brad St. Croix},
  journal={Science Translational Medicine},
Antiangiogenic agents that block vascular endothelial growth factor (VEGF) signaling are important components of current cancer treatment modalities but are limited by alternative ill-defined angiogenesis mechanisms that allow persistent tumor vascularization in the face of continued VEGF pathway blockade. We identified prostaglandin E2 (PGE2) as a soluble tumor-derived angiogenic factor associated with VEGF-independent angiogenesis. PGE2 production in preclinical breast and colon cancer models… CONTINUE READING
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