COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study

@article{Huuskonen2008COX2GP,
  title={COX-2 Gene Promoter Polymorphism and  Coronary  Artery Disease in Middle-Aged Men:  The Helsinki  Sudden Death Study},
  author={Kati H. Huuskonen and Tarja A. Kunnas and Minna M. Tanner and Jussi Mikkelsson and Erkki Ilveskoski and Pekka J. Karhunen and Seppo T Nikkari},
  journal={Mediators of Inflammation},
  year={2008},
  volume={2008},
  pages={345 - 348}
}
Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the -765G-->C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was… CONTINUE READING

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