COX-2-Derived Prostanoids and Oxidative Stress Additionally Reduce Endothelium-Mediated Relaxation in Old Type 2 Diabetic Rats

@inproceedings{Vessires2013COX2DerivedPA,
  title={COX-2-Derived Prostanoids and Oxidative Stress Additionally Reduce Endothelium-Mediated Relaxation in Old Type 2 Diabetic Rats},
  author={Emilie Vessi{\`e}res and A L Guihot and Bertrand Toutain and Maud Maquigneau and C{\'e}line Fassot and Laurent Loufrani and Daniel Henrion},
  booktitle={PloS one},
  year={2013}
}
Endothelial dysfunction in resistance arteries alters end organ perfusion in type 2 diabetes. Superoxides and cyclooxygenase-2 (COX-2) derivatives have been shown separately to alter endothelium-mediated relaxation in aging and diabetes but their role in the alteration of vascular tone in old diabetic subjects is not clear, especially in resistance arteries. Consequently, we investigated the role of superoxide and COX-2-derivatives on endothelium-dependent relaxation in 3 and 12 month-old… CONTINUE READING
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Reactive oxygen species and cyclooxygenase 2-derived thromboxane A2 reduce angiotensin II type 2 receptor vasorelaxation in diabetic rat resistance arteries. Hypertension

  • K Retailleau, EJ Belin de Chantemele, S Chanoine, AL Guihot, E Vessieres
  • 2010
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