COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

@article{To2020COVID19RB,
  title={COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing},
  author={K. To and I. F. Hung and J. Ip and Allen Wing-Ho Chu and W. Chan and A. R. Tam and Carol Ho-Yan Fong and Shuofeng Yuan and Hoi-wah Tsoi and A. Ng and Larry Lap-Yip Lee and Polk Wan and E. Tso and W. To and D. Tsang and K. Chan and Jian-Dong Huang and Kin-Hang Kok and V. C. Cheng and K. Yuen},
  journal={Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
  year={2020}
}
  • K. To, I. F. Hung, +17 authors K. Yuen
  • Published 2020
  • Medicine
  • Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
  • Abstract Background Waning immunity occurs in patients who have recovered from COVID-19. However, it remains unclear whether true re-infection occurs. Methods Whole genome sequencing was performed directly on respiratory specimens collected during two episodes of COVID-19 in a patient. Comparative genome analysis was conducted to differentiate re-infection from persistent viral shedding. Laboratory results, including RT-PCR Ct values and serum SARS-CoV-2 IgG, were analyzed. Results The second… CONTINUE READING
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