COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing

  title={COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing},
  author={Kelvin Kai-Wang To and Ivan F.N. Hung and Jonathan Daniel Ip and Allen Wing-Ho Chu and Wan-Mui Chan and Anthony Raymond Tam and Carol Ho-Yan Fong and Shuofeng Yuan and Hoi‐wah Tsoi and Anthony Chin-Ki Ng and Larry Lee and Polk Wan and Eugene Yuk-Keung Tso and Wing-kin To and Dominic N. C. Tsang and Kwok-Hung Chan and Jian-Dong Huang and Kin-Hang Kok and Vincent Chi-Chung Cheng and Kwok Yung Yuen},
  journal={Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America},
  • K. To, I. Hung, K. Yuen
  • Published 25 August 2020
  • Biology, Medicine
  • Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Abstract Background Waning immunity occurs in patients who have recovered from COVID-19. However, it remains unclear whether true re-infection occurs. Methods Whole genome sequencing was performed directly on respiratory specimens collected during two episodes of COVID-19 in a patient. Comparative genome analysis was conducted to differentiate re-infection from persistent viral shedding. Laboratory results, including RT-PCR Ct values and serum SARS-CoV-2 IgG, were analyzed. Results The second… 
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