COVID-19 pathophysiology: A review

@article{Yuki2020COVID19PA,
  title={COVID-19 pathophysiology: A review},
  author={Koichi Yuki and Miho Fujiogi and Sophia Koutsogiannaki},
  journal={Clinical Immunology (Orlando, Fla.)},
  year={2020},
  volume={215},
  pages={108427 - 108427}
}

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References

SHOWING 1-10 OF 103 REFERENCES
Why is COVID‐19 so mild in children?
There is an urgent need to understand why the course of the coronavirus that started in late 2019 (COVID-19) is affecting different groups of individuals with varying severity during the ongoing
SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far
TLDR
The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development.
SARS-CoV-2 infection in children
TLDR
In order to prevent transmission of SARS-CoV-2, hygienic rules should be pursued in the community, social distancing should be observed, and the family members and contacts of patients who have been diagnosed should be screened and isolated.
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
TLDR
It is shown that the functional exhaustion of cytotoxic lymphocytes is associated with SRAS-CoV-2 infection, which may break down antiviral immunity at an early stage, and the role of NKG2A has been identified to induce NK cell exhaustion in chronic viral infections.
Clinical Characteristics of Coronavirus Disease 2019 in China
TLDR
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
Dysregulation of immune response in patients with COVID-19 in Wuhan, China
  • C. Qin, Luoqi Zhou, Daishi Tian
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2020
TLDR
Investigation of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19 and shows the novel coronavirus might mainly act on lymphocytes, especially T lymphocytes.
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
TLDR
The results demonstrate that excessive non-effective host immune responses by pathogenic T cells and inflammatory monocytes may associate with severe lung pathology and suggest that monoclonal antibodies targeting GM-CSF or interleukin 6 may be effective in blocking inflammatory storms and, therefore, be a promising treatment of severe COVID-19 patients.
Exacerbated Innate Host Response to SARS-CoV in Aged Non-Human Primates
TLDR
It is shown that SARS-CoV-infected aged macaques develop more severe pathology than young adult animals, even though viral replication levels are similar, and the anti-inflammatory action of type I IFN reveals a potential intervention strategy for virus-induced ALI.
Epidemiology of COVID-19 Among Children in China
TLDR
The distribution of children’s COVID-19 cases varied with time and space, and most of the cases were concentrated in Hubei province and surrounding areas, providing strong evidence of human-to-human transmission.
...
1
2
3
4
5
...